Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Summary of the targeted literature searches performed

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Description of the phthalates included in the mandate

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques: Molecular Weight

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Aggregated exposure from indoor environment, food and contact with articles for each phthalate (μg/kg bw per day) (from ECHA, 2017a )

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Restriction parameters for the five phthalates as set out in Regulation (EU) No 10/2011

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques: Control

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Analytical results on phthalates present in the EFSA database after data cleaning. Phthalates under evaluation in this assessment are marked with *

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Number of samples present in the EFSA database for phthalates according to reporting country

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Number of samples in the EFSA database according to sampling year

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques: Sampling

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Statistics on the LOQs (μg/kg) reported in the EFSA database

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Estimated mean and P97.5 of dietary exposure (μg kg/bw per day, LB–UB values) as reported in FSA ( 2010 )

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Estimated exposure of phthalates of the Irish children and adult population from all food groups (μg kg/bw per day) as reported in FSAI, 2016

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Estimated dietary exposure (μg kg/bw per day) for French infants below 3 years from the total population, as reported in ANSES ( 2016a , b )

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Overall intake estimates (μg/kg bw per day) from DEMOCOPHES (calculated for ‘Europe’), based on Den Hond et al. ( 2015 ) (Table adapted from ECHA, 2017a )

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Comparison of dietary exposure estimates for infants/toddlers and adults derived in this opinion (μg/kg bw per day) with estimates from three TDS (UK, IRE, FR), and estimates reported in the ECHA ( 2017a , b ) opinion. Figures are rounded for ease of comparison

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques: Comparison, Derivative Assay

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Major urinary metabolites of the dialkyl ortho‐phthalates discussed in this opinion

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Calculation of RPFs

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Exposure estimates (μg/kg bw per day) from food as calculated in Section 3.4.2.1 . Ranges are the min–max for all ages, all surveys and all countries

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Uncertainty analysis for the exposure assessment

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques: Biomarker Discovery, Migration

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Uncertainty analysis for the hazard identification and characterisation

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Quality assessment of epidemiological studies according to NOS

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Intake estimates (μg/kg bw per day) for mothers from Myridakis et al. ( 2015 ) for Greece, in combination with DEMOCOPHES (Table adapted from ECHA, 2017a )

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques:

Journal: EFSA Journal

Article Title: Update of the risk assessment of di‐butylphthalate ( DBP ), butyl‐benzyl‐phthalate ( BBP ), bis(2‐ethylhexyl)phthalate ( DEHP ), di‐isononylphthalate ( DINP ) and di‐isodecylphthalate ( DIDP ) for use in food contact materials

doi: 10.2903/j.efsa.2019.5838

Figure Lengend Snippet: Intake estimates for food (μg/kg bw per day) (Table adapted from ECHA, 2017a )

Article Snippet: Measurements in rodents exposed orally to low doses of phthalates indicate that gastrointestinal absorption is rapid and that observed levels are close to 100% for DBP and BBP, and about 50% for DEHP, DINP and DIDP (INSERM, ).

Techniques: